Stomach-specific c-Myc overexpression and gastric cancer

Gastric cancer is one of the most common malignant cancers worldwide. Since the stage of early gastric cancer usually lasts for a long time and lacks obvious symptoms, the diagnosis of early gastric cancer is very difficult. Therefore, gastric cancer patients typically have a poor prognosis and low survival rate. During the progression of gastric cancer, genetic factors play an indispensable role. c-Myc, an oncogene, is abnormally highly expressed in a variety of tumors, including gastric cancer. For example, the Hi-Myc mouse model with high expression of c-Myc has been widely used in prostate cancer research. However, there is still no gastric cancer mouse model with increased expression of c-Myc, and it is unclear how c-Myc promotes gastric cancer in the early stage.

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