News

Mental map of space is stabilized by sugar coated neurons


neuron
Credit: Pixabay/CC0 Public Domain

A reliable sense of space is essential for daily life and memory formation. Removing sugar coated proteins around neurons in the brains’ internal gps makes the mental map of space unstable, shows a study published in the journal Nature communications.

Scientists from the University of Oslo, Norway have shown that the sugar coated extracellular matrix proteins, called perineuronal nets, that wrap densely around neurons in the brain, are responsible for long-term stability of the mental maps. This study is the first to link extracellular matrix to the stability of our sense of space.

Every time you revisit a place, neurons will be reactivated in the exact same place telling you where you are. “When we removed the perineuronal nets from neurons in the entorhinal cortex in rats, we observed that new grid maps formed more slowly in novel environments compared to grid cells from rats that had intact perineuronal nets. Even more surprising was that when the
rats returned to their familiar arenas, also the stored grid maps had become unstable,” says main author Charlotte Christensen. “This suggests that the perineuronal nets contribute to maintain the integrity of stored mental maps and prevent them from being overwritten by new experiences.”

Read:Right Time TO Start A Family

They found that not only was the grid map unstable, also the precise timing between grid cell firing was impaired after removal of the perineuronal nets. This opens for future investigations to elucidate if the confusion with time or place in Alzheimer patients is associated with changes in the extracellular matrix of the brain.


Changes in brain cartilage may explain why sleep helps you learn

Read:Study finds potential therapeutic targets to inhibit colorectal cancer progression

More information:
Ane Charlotte Christensen et al. Perineuronal nets stabilize the grid cell network, Nature Communications (2021). DOI: 10.1038/s41467-020-20241-w

Provided by
University of Oslo

Citation:
Mental map of space is stabilized by sugar coated neurons (2021, January 19)
retrieved 19 January 2021
from https://medicalxpress.com/news/2021-01-mental-space-stabilized-sugar-coated.html

Read:Q&A: Top 10 workout myths

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





Source link

Previous post
Cancer-related suicide declined in the US during the past two decades
Next post
Researchers discover potential new therapy for chemotherapy-resistant breast cancer